International Health Sciences Journal (online)
type: channel
description: eISSN: 3051-6501 The International Health Sciences Journal (online) is developed in cooperation with the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, and was launched in 2025. Being a high quality double-blind refereed Journal, the Journal provides an international forum for discussion of current trends and dissemination of knowledge to support evidence-based clinical practice around the World. SCOPE The Journal accepts articles on Clinical Research in all hospital-based Medical Specialties within the main types of research, including: Treatment Research: Focuses on describing medical treatments, including therapeutic or surgical intervention. Screening Research: Investigates and discusses methods for detecting diseases or conditions early. Diagnostic Research: Seeks to describe, discuss and improve diagnostic tests or tools. Genetic Studies: Examines genetic factors related to disease. The favored types of applied research methods include: Observational Studies; Randomized Controlled Trials (RCTs); Cohort Studies; Case-Control Studies; Case-Reports; Authors are expected to follow the applicable international Guidelines for Clinical research reporting, including: Consort for randomized controlled trials STROBE for observational studies CARE for case reports ARRIVE for pre-clinical animal studies See the link for more information on other Guidelines as defined by the Equator Network: https://www.equator-network.org/reporting-guidelines/ Publishing model: Online (Hybrid Journal) eISSN: 3051-6501 Acceptance Rate (2025): n.a. - Rejection Rate (2025): n.a. Average Days for First Decision in 2025: 10 Days Average Days for Publication Online in 2025: 40 days Publishing Fees (NOT APPLIED DURING 2025 and 2026): Open Access (OA) APC: not defined (this is Optional as the Journal is a Hybrid Journal); Authors are not obliged to Publish in OA (please contact the Editorial Office for details). Most articles published in…
publisher: IHR Publishing, Amsterdam, Netherlands (in partnership with SAGE)
language: en
publication name: International Health Sciences Journal (online)
issn: 3051-6501
copyright: Articles are published under a CC Attribution-Non-Commercial-No-Derivatives 4.0 Licence.
items: Airway Remodeling and Inflammation in Asthma
items: Current status and prospect in atrial fibrillation
items: The culprit of chronic complications of diabetes-from glucose to insulin resistance
items: Ethics and Clinical Research
items: The Key Role of Nutritional Interventions in the Prevention and Control of Chronic Diseases
items: The present situation, breakthrough and challenge in the development of thoracic surgery
items: Deep brain Stimulation (DBS) : A leap from history to the future
items: Key challenges and future prospects of microwave ablation in the treatment of small pulmonary nodules and early lung cancer

Airway Remodeling and Inflammation in Asthma
type: item
description: Asthma, a chronic inflammatory disorder of the airways, involves a complex interplay between airway inflammation and airway remodeling. While both processes are well-documented, a more nuanced understanding of how they interconnect offers valuable insights for potential novel treatments. Unlike the more traditional perspectives that view inflammation as the primary driver of remodeling, recent studies suggest that airway remodeling can occur independently of inflammation and may itself be an initiator of immune responses. This paradigm shift prompts a reconsideration of how these processes interact and what this means for the treatment of asthma. Asthma is generally characterized by wheezing, chest tightness, and coughing, which result from airflow obstruction and bronchial hyperresponsiveness. It has long been recognized that inflammation is at the core of these symptoms. Various immune cells, including eosinophils, T-helper 2 (Th2) lymphocytes, and innate immune cells, release pro-inflammatory mediators, which damage the airway epithelium and perpetuate inflammation. This leads to airway hyperresponsiveness and contributes to the remodeling process, which involves permanent structural changes in the airways. Interestingly, recent evidence suggests that airway remodeling is not merely a consequence of inflammation but may occur concurrently or even before significant inflammatory changes are detectable. Airway remodeling refers to changes such as epithelial cell damage, subepithelial fibrosis, smooth muscle hypertrophy and hyperplasia, and increased vascularity. These structural alterations contribute to the chronicity and severity of asthma, affecting lung function in a way that often resists conventional anti-inflammatory treatment. One unique perspective is the role of epithelial-mesenchymal transition (EMT) in asthma. EMT, a process by which epithelial cells lose their differentiated characteristics and gain mesenchymal properties, has been increasingly recogni…
subject: Recent Articles
  topic: section
subject: Asthma
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subject: Airway Remodeling
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subject: Inflammation
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creator: Liang Dong
rights: Copyright (c) 2025 International Health Sciences Journal
date: 2025-02-10
publication date: 2025-02-10

Current status and prospect in atrial fibrillation
type: item
description: Atrial fibrillation (AF) is the most common tachyarrhythmia and significantly increases the risk of death, stroke, heart failure, cognitive impairment, and dementia. The prevalence of AF increases with age and is 5.4% and 4.9% in men and women over 75 years of age. Electrocardiograms are used as the gold standard in the diagnosis of AF, however it is not always readily available. Wearable devices have greatly improved the diagnosis of AF by providing continuous, non-invasive heart rhythm monitoring. The management of AF is a "CARE" model, including the comorbidities and risk factor management, avoiding stroke and thromboembolism, reducing symptoms by rate and rhythm control, evaluation and dynamic reassessment (Gelder et al.,2024). Mechanism study of AF Current understanding shows that atrial fibrosis, atrial electrical remodeling, autonomic nervous system (ANS) imbalance, epicardial adipose tissue, chronic inflammation and other factors have important effects on the pathogenesis of AF, but the exact mechanism of AF is still not completely clear, and is still the focus of research at this stage. Complications and risk factors management A variety of risk factors can increase the susceptibility to AF and promote the occurrence and maintenance of AF. Patients with AF should be evaluated for cardiovascular risk factors and comorbidities, including obesity, inappropriate exercise, alcohol consumption, smoking, diabetes, hypertension, and obstructive sleep apnea syndrome. Therefore, AF patients should carry out weight control, reasonable exercise, reduce alcohol consumption, quit smoking and other lifestyle improvements, and strictly control blood pressure. In diabetic patients with AF, SGLT-2i reduces the risk of new AF and recurrence after ablation. In addition to the above risk factors, new risk factors will also increase the risk of new onset and recurrence of AF, including hyperhomocysteinemia, hyperuricemia, hypoalbuminemia, etc. It is also important to seek new in…
subject: Recent Articles
  topic: section
subject: Stroke
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subject: Atrial fibrillation
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subject: Rhythm control
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creator: Yinglong Hou
rights: Copyright (c) 2025 International Health Sciences Journal
date: 2025-02-10
publication date: 2025-02-10

The culprit of chronic complications of diabetes-from glucose to insulin resistance
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description: The prevalence of diabetes and its complications has been increasing exponentially worldwide, especially in China with approximately one-quarter of the global diabetes population. And constitute a major public health problem (Diabetes in China part 1, 2024). As hyperglycemia is the distinguishing feature of diabetes, and also supposed to be the most important risk factor for long-term complications in diabetes by evidence from clinical trials and longitudinal population-based studies (Buse JB et al., 2020), controversy over the target level of glucose control in diabetes lasted more than a decade. The two earliest trials in type 2 diabetes, the United Kingdom Prospective Diabetes Study (UKPDS) in 1970 and the University Group Diabetes Program (UGDP) study in 1998 did not reveal a reduction of cardiovascular endpoints through improved metabolic control(C L Meinertet al., 1970; UK Prospective Diabetes Study (UKPDS) Group,1998). Therefore, the effect of improved glucose control on coronary complications in this population remains questionable. After 2006, three randomized control trials (ACCORD, ADVANCE, Veterans Affairs Diabetes), assessed the impact on cardiovascular events of intensive glucose-lowering therapy (Gerstein HCet al., 2008; Goff DC Jr et al., 2007; Patel A et al., 2008; Robins et al., 2007). None of these studies was able to demonstrate a significant reduction of cardiovascular outcomes in the intensive group (with a HbA1c target of less than 6.0%) as compared to the standard group (with a HbA1c target of 7.0% to 7.9%). Unexpectedly, the ACCORD study was terminated early because of a higher mortality in the intensively group. In contrast, in ACCORD, the study with the most ambitious goal (HbA1c < 6%), the overall and cardiovascular mortality was greater in the intensive group. Meanwhile, in the ADVANCE trial, the mortality and the incidence of cardiovascular events were not statistically different between the two treatment groups. Notably, Veterans Affai…
subject: Recent Articles
  topic: section
subject: Diabetes
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subject: Glucose
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subject: Insulin resistance
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creator: Lin Liao
rights: Copyright (c) 2025 International Health Sciences Journal
date: 2025-02-10
publication date: 2025-02-10

Ethics and Clinical Research
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description: Clinical research must follow a set of principles that fall into internationally recognized ethical research guidelines. Amongst the most relevant aspects, it is accepted that the Social and clinical value of all published research should be clear, as well as its Scientific validity, a transparent subject and topic selection free from conflicts of interest. Other international guiding principles include independent reviews, informed consent when required and respect for all potentially enrolled individuals. Additionally, it is also recognized internationally that a favorable risk-benefit ratio of the published research should be demonstrated and its social and clinical value should also be argued. All studies are designed to answer a specific research question, or the problem tackled by the published article. The answer should be important enough to justify the effort of publishing. In other words, answers to the research question should contribute to promote a better scientific understanding of disease processes, diagnosis or therapeutic or other type of clinical intervention. Hence, the challenge of avoiding bias in clinical research has been identified as a rather challenging ethical issue which an ongoing current international debate. This new journal will provide us with an excellent platform. It will bring together the wisdom of the field on a global scale, facilitating a meeting of the minds and helping us to overcome the current challenges. By publishing the in International Health Sciences Journal, your research results will gain wider international exposure and attract the attention of global peers, thus further promoting the development of your research. At the same time, the rigorous peer-review mechanism will ensure that each article will be strictly controlled in terms of academic quality, which will help you to continuously improve your research methodology and research level. I would like to appeal to all readers to actively contribute to this journa…
subject: Recent Articles
  topic: section
subject: Clinical Research
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subject: Research Methods
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subject: Ethics
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creator: Yunfeng Li
rights: Copyright (c) 2025 Yunfeng Li (Author)
date: 2025-02-10
publication date: 2025-02-10

The Key Role of Nutritional Interventions in the Prevention and Control of Chronic Diseases
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description: With the advancement of economic development and changes in lifestyle, chronic diseases have become a significant global health threat and economic burden. According to the World Health Organization (WHO) (WHO, 2023), approximately 41 million people die each year from chronic diseases, accounting for 74% of all global deaths. Cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes together account for more than 80% of chronic disease-related mortality. Numerous studies show that 86% of cardiovascular diseases, 73% of diabetes-related deaths, and 70% of cancer-related deaths could be prevented or controlled through effective interventions. However, traditional medical approaches primarily focus on disease treatment and have not fundamentally addressed the rising health and economic burden posed by the increasing prevalence of chronic diseases. In recent years, mounting evidence has highlighted the critical role of dietary and nutritional interventions in both the prevention and management of chronic diseases. This paper aims to review the latest advances in nutritional interventions for chronic disease management, particularly focusing on salt reduction, sugar reduction, and dietary pattern interventions, and to propose new insights for integrating nutritional strategies into chronic disease management. Dietary factors are key contributors to the development and progression of chronic diseases, with salt intake, sugar consumption, and dietary patterns being major areas of current research. Studies have shown that high salt intake significantly increases the risk of hypertension and cardiovascular diseases, particularly among middle-aged and older populations. Currently, global salt consumption far exceeds the recommended levels outlined in health guidelines, which poses a severe threat to public health. Salt reduction interventions have yielded significant success in controlling hypertension and cardiovascular diseases in several countries and re…
subject: Recent Articles
  topic: section
subject: Chronic Diseases
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subject: Nutritional Interventions
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subject: Prevention and Control
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creator: Jixiang Ma
rights: Copyright (c) 2025 International Health Sciences Journal
date: 2025-02-10
publication date: 2025-02-10

The present situation, breakthrough and challenge in the development of thoracic surgery
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description: The incidence and mortality of lung cancer and esophageal cancer in China are among the top in the world. Most patients have reached the middle and late stage when diagnosed. The five-year survival rate of lung cancer is only 16%, and that of esophageal cancer is less than 20%. Obviously, early diagnosis and treatment is the key to improve the survival rate of patients, and the healthy development of thoracic surgery plays an important role in improving the quality of life of patients with chest tumors. At present, the field of thoracic surgery is being strongly driven forward by ten key directions. "Surgical robot digital medical" integrates top technology, high-precision robotic arm and intelligent imaging system, making surgical operation accurate and micro, opening up a new situation for the treatment of complex diseases; "Lung Transplant Surgery Practice" to overcome the problems of lung source acquisition, surgical anastomosis, anti-rejection, for patients with end-stage lung disease to continue life. "Accelerated rehabilitation surgical process management" runs through the whole perioperative period, fine-adjusting fasting and drinking, precise analgesia, and encouraging early activities of patients to shorten hospital stay and improve medical experience. "Fine control of Medical quality" strictly controls all aspects of medical treatment, standardizes the diagnosis and treatment process with high standards, supervises medical behavior, and ensures that patients receive homogeneous, efficient and safe services; "Multidisciplinary collaborative diagnosis and treatment" breaks the disciplinary barriers, integrates the wisdom of internal medicine, surgery, imaging, pathology and other professionals, and tailors the best comprehensive treatment plan for difficult and complicated diseases; "Perioperative health management model construction" covers the whole surgical cycle, accurate preoperative assessment, careful care during the operation, and continuous follow-…
subject: Recent Articles
  topic: section
subject: Surgical robot digital medical
  topic: keywords
subject: Fine control of Medical quality
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subject: Thoracic surgery
  topic: keywords
creator: Hui Tian
rights: Copyright (c) 2025 International Health Sciences Journal
date: 2025-02-10
publication date: 2025-02-10

Deep brain Stimulation (DBS) : A leap from history to the future
type: item
description: Deep Brain Stimulation (DBS), as a revolutionary method of neuroregulation, has shown remarkable efficacy in the treatment of movement disorders such as Parkinson's disease and dystonia. In recent years, with the continuous advancement of technology and the expansion of research fields, DBS is gradually becoming a key tool in the exploration of complex neurological and psychiatric disorders. This paper briefly reviews the history, current research hotspots and future challenges of DBS, and sincerely invites academic colleagues to actively participate in the exploration and submission of this field. History: From creation to prosperity The origins of DBS technology can be traced back to functional neurosurgery in the 20th century. Early advances in functional localization technology enabled neurosurgeons to accurately locate intracranial structures and perform lesion excision with stereotactic devices, but these operations were often associated with irreversible nerve damage and significant side effects. In the 1950s, high-frequency electrical stimulation was first shown to be effective in inhibiting abnormal nerve signaling, thereby relieving symptoms of tremors and dyskinesia. In the 1980s, a research team in Grenoble, France, pioneered the application of high-frequency stimulation to the subthalamic nucleus to treat Parkinson's disease, and achieved a therapeutic effect comparable to, but more adjustable and reversible than, focal resection surgery (Limousin et al., 1995). This milestone has been hailed as "another miracle in the treatment of Parkinson's disease after levodopa." Since then, DBS technology has been gradually promoted and expanded to other movement disorders and mental illness treatment areas. Current research focus: the dual progress of technology and mechanism In recent years, the development of DBS technology has entered a new stage of interdisciplinary and innovation-driven development. The following three directions are the main research hotspo…
subject: Recent Articles
  topic: section
subject: Deep brain Stimulation
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subject: DBS
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subject: Neuroregulation
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creator: Tao Xin
rights: Copyright (c) 2025 International Health Sciences Journal
date: 2025-02-10
publication date: 2025-02-10

Key challenges and future prospects of microwave ablation in the treatment of small pulmonary nodules and early lung cancer
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description: Driven by the rapid development of minimally invasive surgical techniques, the treatment of small lung nodules and early lung cancer has ushered in epoch-making changes. In particular, Microwave ablation (MWA) technology, as a potential treatment for the treatment of small lung nodules and early lung cancer, received high attention in the industry. MWA, with its unique advantages of minimally invasive, rapid recovery and low complication rate, is gradually subverting the traditional nodule/early lung cancer treatment model. However, although MWA has achieved remarkable results in the clinical treatment process, it still faces some key challenges. The purpose of this article is to explore these key challenges in depth and to look into the future development of microwave ablation in the treatment of pulmonary nodules/early lung cancer. Microwave ablation is a minimally invasive treatment that uses microwave energy to generate heat, effectively destroy tumor cells while maximizing the preservation of surrounding healthy lung tissue. Its significant effectiveness and safety have been widely recognized in the industry, providing an alternative for lung nodules and early lung cancer patients who are not suitable for surgery and cannot tolerate surgery. However, there are still several challenges in clinical practice: Precise location and puncture of pulmonary nodules and lung cancer. It is a challenge to accurately identify and puncture small lung nodules and early lung cancer, especially the aerated organs in the bidirectional movement of exhalation and inhalation in the lung at this moment, and the difficulty of accurate positioning and puncture is much higher than that of other organs. Our team first proposed the concept of "tumor ablation area". Firstly, the concept of multi-dimensional properties of "tumor lesion area (GTR)" and "post-ablation target area (PTZ)" in ablation was proposed, which laid a theoretical foundation for accurate ablation and complete ablation.…
subject: Recent Articles
  topic: section
subject: Lung cancer
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subject: Pulmonary nodules
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subject: Microwave ablation
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creator: Xin Ye
rights: Copyright (c) 2025 International Health Sciences Journal
date: 2025-02-10
publication date: 2025-02-10